About the role:

We are looking for an outstanding scientist to join ourApplications Team. You will be part of a highly collaborative R&D team working to demonstrate the value of 10x products. As a scientist in this position, you will work in two key areas covered by the Applications team: the Catalyst program and Application demonstrations. The Catalyst program delivers Xenium data to customers generated using their samples. Here, you will be responsible for library preparation, instrument operation, and initial analysis and QC of the data. To develop Application demonstrations you will apply your understanding of biology to design and execute experiments that allow us to better understand the biological questions that can be answered using 10x technologies. The successful candidate in this position will work closely with expert scientists in spatial single cell analysis and has the opportunity to participate in high profile cutting edge biological and disease-related research projects from pharma and academic researchers.

You have a strong background in the biological sciences and you have experience working with single cell and spatial genomic assays. You have a deep understanding of biology at the cellular and molecular level and are able to discuss how this relates to health and disease. You are a good wet-lab scientist who can take an idea and quickly design an experiment that allows you to gain a better understanding of the biology of a sample. You are able to communicate your ideas and work effectively with an interdisciplinary team and incorporate their feedback into your experimental design. You are a strategic thinker, highly motivated, proactive and flexible in changing direction and methods. You thrive in a fast paced environment, excel at managing multiple priorities, communicate clearly and get the job done.

What you will be doing:

• Catalyst program
• Use customer samples to generate data using the Xenium in situ platform
• Xenium library preparation workflows
• Initial data QC, analysis and project write up
• Follow compliance processes and maintain relevant documentation for record keeping related to the projects
• Application demonstrations
• Conceive of and execute projects that demonstrate the power of 10x technologies in exploring novel biological insights
• Work with internal groups at 10x to analyze data, generate figures and provide guidance on write up and data presentation
• Present your findings internally and externally at research meetings or conferences

To be successful, you will have:

• A PhD in the applied biological sciences (e.g. cancer research, neuroscience, or similar)
• Experience with molecular biology techniques including immunostaining and/or in situ hybridization techniques (e.g. FISH, RNAscope, in situ hybridization)
• Familiarity with NGS library preparation workflows for single cell and spatial RNA-seq
• A problem solving mentality, you are someone who obsesses over finding useful biologically relevant information in complex datasets
• Evidence of peer-reviewed publications you have authored / co-authored and presentation of your work at conferences
• Ability to work in a fast-paced and quickly changing environment
• Ability to communicate complex ideas with an interdisciplinary team
• Ability to work independently

Additionally, we'd like to see:

• Tissue handling experience (fresh frozen, FFPE, cryosectioning, antigen retrieval, etc.)
• Strong organizational skills, the ability to plan and structure your work, and work to deadlines
• Excellent interpersonal skills, including written and oral communication
• Ability to work in a fast-paced and quickly changing environment
• Work experience from similar positions in academia, industry or a service provider/core facility