The Principal Investigators Ulf Dettmer and Nagendran Ramalingam in the Ann Romney Center

for Neurologic Diseases, Brigham & Women's Hospital, and Harvard Medical School jointly invite

applications from recent graduates for two fully NIH-funded postdoc positions to study the

pathophysiology of alpha-synuclein. The research projects will focus on a) understanding the

physiology of Ser129 phosphorylated alpha-synuclein "pS129" in vivo and b) understanding the

role of pS129 on pathological spreading of alpha-synuclein aggregation in vivo. The ideal

candidate with strong animal work experience will work with novel knock-in mouse models that

have been generated for these projects. Both projects are relevant for Parkinson's disease and

Lewy body dementia.

The projects are built upon two research papers: https://www.nature.com/articles/s41531-023-

00444-w and https://www.embopress.org/doi/full/10.15252/embr.202357145

Candidates must have extensive experience working with mice. Prior experience in survival

surgery or electrophysiology is highly desirable. Only candidates with demonstrated expertise and

publications in molecular biology, biochemistry, imaging, and animal husbandry should apply.

A competitive salary will be provided.

Requirements

* A Ph.D. in neuroscience, biochemistry, or a related biological field.

* Excellent track record of publications.

* Extensive experience with mouse studies, including behavioral analysis, listed in detail in

the CV.

* Experience in molecular biology, imaging, and biochemistry, listed in detail in the CV.

* Cell culture (primary neurons) experience preferred, listed in detail in the CV.

* Self-motivated and driven individuals able to work both independently and in a team

environment.

* Excellent oral and written communication skills in English.

* Minimum three-year commitment.

As there may be numerous applicants, we apologize in advance for not replying to every email

while we recruit candidates with all of the above qualifications.

To apply, interested applicants should send a CV with the contact information of 3 references and

a cover letter detailing research experience/accomplishments with a potential start date directly

to ktobin11@bwh.harvard.edu.

BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.