Senior Scientist, InVivo Pharmacology (Preclinical Development)
Watertown, MA 
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Job Description

Job Description

Vertex Pharmaceuticals is working to discover and develop innovative genetic therapies with the potential to provide transformative benefit to patients. Vertex is currently advancing multiple CRISPR-based genetic therapies that have the potential to cure or stop the progression of disease, including for degenerative neurological and muscular diseases. Vertex is seeking a creative, self-motivated individual with a passion for science to join our team. This is a fantastic opportunity to work on cutting edge science, apply state-of-the-art gene editing technologies, and take part in discovering and developing next-generation therapies for Duchenne Muscular Dystrophy, Myotonic Dystrophy Type 1 and other genetic disorders.

KEY RESPONSIBILITIES

  • Assume responsibility for IND-enabling in vivo studies to advance our lead development programs, including study planning, protocol design, study execution, data analysis and study report writing
  • Oversee CRO management for outsourced preclinical activities
  • Implement good documentation practices
  • Manage in vivo model development and characterization
  • Effectively collaborate with a fully integrated team to facilitate the success of projects

REQUIREMENTS

  • PhD or equivalent in a relevant biological discipline and at least 5 years of relevant pharmaceutical industry experience.
  • Experience in CRO management and oversight for preclinical study execution
  • Deep understanding of drug discovery, gene therapy, applied pharmacology and drug development.
  • Demonstrated implementation of good documentation standards to support regulatory filings
  • Working experience with AAV vectors and/or CRISPR/Cas9 system.
  • Familiarity with the preclinical regulatory requirements for gene therapy/editing programs.
  • Excellent communication skills with the proven ability to work effectively as a member of a multidisciplinary team.

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Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.


Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Human Resources at ApplicationAssistance@vrtx.com.

 

Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Doctorate
Required Experience
5+ years
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