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Job Description
In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat-and even cure-several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex's continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.
KEY RESPONSIBILITIES
- Assume responsibility for IND-enabling in vivo studies to advance our lead development programs, including study planning, protocol design, study execution, data analysis and study report writing
- Oversee CRO management for outsourced preclinical activities
- Implement good documentation practices
- Manage in vivo model development and characterization
- Effectively collaborate with a fully integrated team to facilitate the success of projects
REQUIREMENTS
- PhD or equivalent in a relevant biological discipline and at least 5 years of relevant pharmaceutical industry experience.
- Experience in CRO management and oversight for preclinical study execution
- Deep understanding of drug discovery, gene therapy, applied pharmacology and drug development.
- Demonstrated implementation of good documentation standards to support regulatory filings
- Working experience with AAV vectors and/or CRISPR/Cas9 system.
- Familiarity with the preclinical regulatory requirements for gene therapy/editing programs.
- Excellent communication skills with the proven ability to work effectively as a member of a multidisciplinary team.
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Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Human Resources at ApplicationAssistance@vrtx.com.